#20 new
Krystal Beily

peptide drug conjugate

Reported by Krystal Beily | February 2nd, 2024 @ 06:24 PM

The principle of peptide-drug conjugate (PDC) is to conjugate cell-targeting peptides with drug molecules to enhance drug targeting and to concentrate the drug in the target tissue, thus reducing its relative concentration in other tissues, increasing effectiveness and reducing adverse effects. The peptides used in PDCs include cell-targeting peptides (CTPs) and cell-penetrating peptides (CPPs). Various linkers have been used in PDCs development to prevent unspecific release of the drug. Payloads available in the PDCs include cytotoxic drugs and radionucleotides. PDC integrates the advantages of peptides with low molecular weight and biodegradability, while not causing immunogenic reactions.

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