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High-order chromatin architecture and nucleosomes are effective ways to package the entire genome. Gene silence results from this structure's ability to inhibit the binding of transcription factors and other DNA-binding proteins. The disturbance of nucleosome organization caused by cis-acting DNA elements like as enhancers, promoters, insulators, and other chromatin-binding proteins is closely linked to transcription activation. Remodeled actively and dynamically throughout the genome, chromatin accessibility controls gene expression and cell programming, which are controlled by different cis-acting DNA elements (Fig. 1). Thus, chromatin accessibility research identifies the epigenomic pathways underlying particular cellular functions in both healthy and pathological conditions.

We offer several approaches to test chromatin accessibility based on your unique needs. Please contact our scientists if you would want more information about your program in detail.

The ATAC-seq assay, which uses sequencing to assess transposase-accessible chromatin,

ATAC-seq is able to produce genome-wide profiles of accessible regions of chromatin by relying on the transposase-mediated insertion of sequencing primers into particular chromatin regions. We provide this technology to assist our clients in identifying the chromatin's active regulatory areas.