#38 new
Gemini Smith

ADCC/CDC Mechanism

Reported by Gemini Smith | March 26th, 2024 @ 06:44 PM

In ADCC, an immune effector cell's Fcγ receptor (also known as FCGR or FcηR) binds to a specific Fc region of an antibody, activating effector cells and causing them to secrete chemicals including TNF, granzyme, lyase, and perforin that may subsequently facilitate the destruction of target cells. When C1q attaches to antibodies in CDC, the complement cascade and membrane attack complexes (MAC) (C5b to C9) that develop on target cell surfaces are activated, which in turn activates the classical route complement. Both of these methods rely heavily on the complement system's activation mechanism as well as the glycoprotein and protein structure in the Fc region. Our dual ADCC/CDC enhancement technology will be primarily focused on the two qualities mentioned above.

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